More About the Stem Cell Unit
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The NIH Stem Cell Unit (l-r): Kye-Yoon Park, Barbara Mallon, Rebecca Hamilton, and Kevin Chen.
To allow scientists to select which lines are most suitable for their intended experiments, the research community has consistently requested that available cell lines be more fully characterized.
To address this important need, the NIH Intramural Research Program has created the NIH Stem Cell Unit (SCU). The SCU has established a database to which hESC
lines, adult stem cells and induced pluripotent stem (iPS) cells may be
directly compared. These data give scientists the information they need when
choosing individual cell lines for specific projects.
The Unit's main goal is to identify—and share with the research community—the similarities and differences between the hESC lines when subjected to a standardized paradigm.
The assays performed by this Unit are overseen by a steering committee of leading stem cell biologists in both the extramural and NIH intramural research community. Pamela Gehron Robey, Ph.D. of NIDCR is the Acting Director and provides day-to-day direction.
- Chen KG, Mallon BS, Mckay RD, Robey PG. Human pluripotent stem cell culture: considerations for maintenance, expansion, and therapeutics. Cell Stem Cell. 2014;14(1):13–26.
- Chen KG, Mallon BS, Johnson KR, Hamilton RS, Mckay RD, Robey PG. Developmental insights from early mammalian embryos and core signaling pathways that influence human pluripotent cell growth and differentiation. Stem Cell Res. 2014;12(3):610–621.
- Mallon BS, Hamilton RS, Kozhich OA, et al. Comparison of the molecular profiles of human embryonic and induced pluripotent stem cells of isogenic origin. Stem Cell Res. 2014;12(2):376–86.
- StemCellDB: The Human Pluripotent Stem Cell Database at the National Institutes of Health, Stem Cell Research.
- Regulation and Expression of the ATP-binding Cassette (ABC) Transporter, Stem Cells.
- Non-Colony Type Monolayer Culture of Human Embryonic Stem Cells, Stem Cell Research.
- Standardized Generation and Differentiation of Neural Precursor Cells from Human Pluripotent Stem Cells, Stem Cell Reviews [Epub ahead of print].
- Hepatic Differentiation from Human Embryonic Stem Cells Using Stromal Cells, The Journal of Surgical Research [Epub ahead of print].
- Characterization of human embryonic stem cell lines by the International Stem Cell Initiative, Nature Biotechnology.
- Toward xeno-free culture of human embryonic stemcells (640k PDF; get Adobe Reader), NIH Stem Cell Unit, The International Journal of Biochemistry & Cell Biology.
- Kuznetsov SA, Cherman N, Robey PG. In vivo bone formation by progeny of human embryonic stem cells. Stem Cells and Development. 2010 Sep 14 [Epub ahead of print].
- Cimato T, Beers J, Ding S, Ma M, McCoy JP, Boehm M, Nabel EG. (2009) Neuropilin-1 identifies endothelial precursors in human and murine embryonic stem cells before CD34 expression. Circulation. 119(16):2170–8.
- Xing Yan, Haiyan Qin, Cunye Qu, Rocky S Tuan, Songtao Shi, George TJ Huang. (2009) iPS cells reprogrammed from mesenchymal-like stem/progenitor cells of dental tissue origin. Stem Cells and Development. 19(4):469–80.
NIH Stem Cell Unit Citations
NIH Stem Cell Unit in the News