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Stem Cell Information

Database of Publications Featuring Mouse Embryonic Stem Cell Lines

In the last three decades, stem cells have greatly impacted biomedical research and have advanced our understanding of many diseases, including diabetes, muscular dystrophy, cystic fibrosis, and osteoporosis. Many of the breakthroughs in the application of stem cells have been made using proliferative cells derived from mouse embryos. In 1981, the first mouse embryonic stem (ES) cell lines were isolated and grown in culture. These cells were among the first to be shown to grow in an undifferentiated state for long periods of time and to be capable of differentiating into multiple cell types. Following this discovery, mouse ES cells rapidly became an indispensable tool for discovery in biomedical research.

Mouse ES cell lines have enabled notable basic scientific discoveries in areas such as cell cycle regulation, spatial and temporal relationships during development, and the roles of various transcription factors and homeobox genes in developmental pathways. Furthermore, homologous recombination between modified gene constructs and the ES cell genome has allowed scientists to establish hundreds of transgenic mice that feature a single, targeted genetic change, thereby illuminating the relationships between individual genes and disease states. As an enabling technology, mouse ES cells have influenced many related fields of research, including drug-development paradigms, directed differentiation to treat specific diseases, and nuclear transfer protocols used in cloning.

In the two decades that followed the establishment of mouse ES cells, more than 1300 peer-reviewed publications have included mouse ES cell lines as a research emphasis. Hundreds of new cell lines have been created, many of which have yielded valuable information about specific diseases. As a resource for researchers, the NIH has created a searchable database of publications from 1981 to 2001 that feature mouse ES cell lines. As applications of ES cell biology progress from a discovery tool to applied technologies for medicine, research using mouse ES cell lines will continue to enable extraordinary achievements.

Click here for the Criteria for the Selection of Scientific Publications that Feature Mouse Embryonic Stem Cell Lines.

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